Synthesis and deamination of 7, 12-dihydrobenz [a] anthracen-7, 12-imines. A new benz [a] anthracene synthesis

GW Gribble, CS LeHoullier, MP Sibi…

文献索引：Gribble, Gordon W.; LeHoullier, Craig S.; Sibi, Mukund P.; Allen, Robert W. Journal of Organic Chemistry, 1985 , vol. 50, # 10 p. 1611 - 1616

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被引用次数: 25

摘要

CDR= H, CH, it seemed important to synthesize and have screened for carcinogenicity selected polyfluorinated PAH in which one (or both) of the terminal rings was completely 'blocked” toward metabolism. Furthermore, it might be proposed that a meta arrangement of two fluorines would suffice to block metabolism in the substituted ring and be less susceptible to nucleophilic displacement than a tetrafluoro-substituted ring. Thus, one ...