An Efficient Approach for the Synthesis of N??1 Substituted Hydantoins

…, MP Kaushik, A Mazumdar

文献索引：Kumar, Vinod; Kaushik; Mazumdar, Avik European Journal of Organic Chemistry, 2008 , # 11 p. 1910 - 1916

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被引用次数: 4

摘要

Abstract An efficient three-step route for the synthesis of N-1 alkyl/aryl-substituted hydantoins was developed from inexpensive commercially available substrates. The reaction of amines with cyanogen bromide takes place to give monoalkyl/aryl cyanamides. This on treatment with methyl bromoacetate in the presence of sodium hydride in tetrahydrofuran affords methyl N-cyano-N-alkyl/arylaminoacetate, which undergoes hydrolysis and cyclization in ...