Aroyl (aminoacyl) pyrroles, a new class of anticonvulsant agents

…, JL Vaught, HR Almond, JP Stables…

文献索引：Carson, John R.; Carmosin, Richard J.; Pitis, Philip M.; Vaught, Jeffry L.; Almond, Harold R.; Stables, James P.; Wolf, Harold H.; Swinyard, Ewart A.; White, H. Steve Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1578 - 1584

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被引用次数: 43

摘要

2-Aroyl-4-(ω-aminoacyl)-(4) and 4-aroyl-2-(ω-aminoacyl) pyrroles (9) represent a new, structurally novel class of anticonvulsant agents. Compounds of type 4 were prepared by Friedel-Crafts acylation of a 2-aroylpyrrole with an ω-chloroacyl chloride followed by displacement of the chloro group by a primary or secondary amine. Compounds of type 9 were prepared by Friedel-Crafts aroylation of a 2-(ω-chloroacyl) pyrrole followed by ...