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Tetrahedron

New synthesis of 3-aryl-Nn-propyl-piperidines

MY Chang, ST Chen, NC Chang

文献索引：Chang, Meng-Yang; Chen, Shui-Tein; Chang, Nein-Chen Tetrahedron, 2002 , vol. 58, # 18 p. 3623 - 3628

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被引用次数: 27

摘要

The synthesis of 3-aryl-Nn-propyl-piperidines is described in six steps starting from α- sulfonyl acetamide via the formal [3+ 3] cycloaddition reaction of the latter into glutarimide. The pathway involves an efficient cycloaddition and regioselective reduction, and yields useful building blocks for heterocyclic chemistry.

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