Enzyme-promoted desymmetrisation of prochiral bis (cyanomethyl) phenylphosphine oxide

P Kiełbasiński, M Rachwalski, M Kwiatkowska…

文献索引：Kielbasinski, Piotr; Rachwalski, Michal; Kwiatkowska, Malgorzata; Mikolajczyk, Marian; Wieczorek, Wanda M.; Szyrej, Malgorzata; Sieron, Leslaw; Rutjes, Floris P.J.T. Tetrahedron Asymmetry, 2007 , vol. 18, # 17 p. 2108 - 2112

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被引用次数: 14

摘要

Prochiral bis (cyanomethyl) phenylphosphine oxide has been successfully transformed into the corresponding optically active monoamide and monoacid with enantiomeric excesses ranging from low (15%) to very high (up to 99%) using a broad spectrum of nitrile- hydrolysing enzymes.