Tetrahedron letters

Novel quenchers for solution phase parallel synthesis

SS Nikam, BE Kornberg, SE Ault-Justus, MF Rafferty

文献索引：Nikam, Sham S.; Kornberg, Brian E.; Ault-Justus, Stephanie E.; Rafferty, Michael F. Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1121 - 1124

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被引用次数: 21

摘要

The bifunctionality of amino acids can be exploited by utilizing them as quenchers in rapid solution phase parallel synthesis. The amino group was used to covalently trap the excess electrophiles, whereas the carboxylic acid moiety was used to solubilize the derivatized amino acid in water. As a prototype we used potassium sarcosinate as a quencher for excess electrophiles in the acylation or sulfonation of N-methyl-benzylamine. Various ...