Tetrahedron letters

An expeditious synthesis of a biscyclam with an aromatic linker

D Xu, PG Mattner, K Prasad, O Repic, TJ Blacklock

文献索引：Xu, Daqiang; Mattner, Paul G.; Prasad, Kapa; Repic, Oljan; Blacklock, Thomas J. Tetrahedron Letters, 1996 , vol. 37, # 30 p. 5301 - 5304

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被引用次数: 20

摘要

An efficient synthesis of 1 starting from N, N′-bis (3-aminopropyl) ethylenediamine 2 is described. Two salient features of the present work are the selective bis or tris- trifluoracetylation of 2 and a novel bis-macrocyclization of the hexatosyl intermediate 5 using ethylene glycol ditosylate.