Chinese Chemical Letters

3-(Diphenylphosphino) propanoic acid: An efficient ligand for the Cu-catalyzed N-arylation of imidazoles and 1H-pyrazole with aryl halides

YS Liu, Y Liu, XW Ma, P Liu, JW Xie, B Dai

文献索引：Liu, Ya-Shuai; Liu, Yan; Ma, Xiao-Wei; Liu, Ping; Xie, Jian-Wei; Dai, Bin Chinese Chemical Letters, 2014 , vol. 25, # 5 p. 775 - 778

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被引用次数: 5

摘要

3-(Diphenylphosphino)propanoic acid (L2) has proved to be an efficient ligand for the copper-catalyzed C N coupling reactions. N-arylation of imidazoles with aryl iodides catalyzed by CuCl/L2 was smoothly carried out in DMSO at 100 °C with a yield up to 98%. N-arylation of 1H-pyrazole with aryl iodides and bromides catalyzed by Cu(OAc) 2 /L2 in 1,4-dioxane also gave the corresponding products with yields of 40%–98%. ... 3-(Diphenylphosphino)propanoic ...