Romazarit. A potential disease-modifying antirheumatic drug

…, JC Wickens, DP Bloxham, D Bradshaw

文献索引：Self; Barber; Machin; Osbond; Smithen; Tong; Wickens; Bloxham; Bradshaw; Cashin; Dodge; Lewis; Westmacott Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 772 - 777

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被引用次数: 20

摘要

The disease modifying antirheumatic drugs (DMARDs) which are available in current clinical practice are considerably limited by their narrow therapeutic ratio and by the severity of their side effects. l Therefore there is a demonstrable need for DMARDs of increased potency coupled with reduced adverse effects. The development of such agents by rational means has been hampered by the paucity of detailed information on the mechanisms of action of ...