Synthesis and voltage-clamp studies of methyl 1, 4-dihydro-2, 6-dimethyl-5-nitro-4-(benzofurazanyl) pyridine-3-carboxylate racemates and enantiomers and of their …
S Visentin, P Amiel, R Fruttero, D Boschi…
文献索引：Visentin, Sonja; Amiel, Pascale; Fruttero, Roberta; Boschi, Donatella; Roussel, Christian; Giusta, Laura; Carbone, Emilio; Gasco, Alberto Journal of Medicinal Chemistry, 1999 , vol. 42, # 8 p. 1422 - 1427
Racemic methyl 1, 4-dihydro-2, 6-dimethyl-5-nitro-4-(benzofurazanyl) pyridine-3- carboxylates (±)-10 and (±)-11 and their benzofuroxanyl analogues (±)-12 and (±)-13 were prepared using a modified Hantzsch reaction that involved the condensation of nitroacetone with methyl 3-aminocrotonate and the appropriate aldehydes. The racemic mixtures were resolved into the corresponding enantiomers. Whole-cell voltage-clamp studies on L-type ...
