Novel 6, 7-diphenyl-2, 3, 8, 8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents

…, A Venkateswarlu, S Rajagopal, R Ajaykumar…

文献索引：Sharma, Vedula M.; Adi Seshu; Vamsee Krishna; Prasanna; Chandra Sekhar; Venkateswarlu; Rajagopal, Sriram; Ajaykumar; Deevi, Dhanvanthri S.; Rao Mamidi; Rajagopalan Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 10 p. 1679 - 1682

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被引用次数: 21

摘要

A series of 6, 7-diphenyl-2, 3, 8, 8a-tetrahydro-1H-indolizin-5-one analogues were synthesized and evaluated for cytotoxic activity against eight human cancer cell lines. Compounds 18, 21, 28, 29, 30 and 31 showed cytotoxic activity with GI50 values in the range of 2.1–8.1 μM concentration. Among these, compounds 21 and 28 exhibited good pharmacokinetic properties. These compounds were further evaluated for their in vivo ...