On the mechanism of the copper-catalyzed enantioselective 1, 4-addition of Grignard reagents to α, β-unsaturated carbonyl compounds

…, A Meetsma, AJ Minnaard, BL Feringa

文献索引：Lopez, Fernando; Harutyunyan, Syuzanna R.; Meetsma, Auke; Minnaard, Adriaan J.; Feringa, Ben L. Angewandte Chemie - International Edition, 2005 , vol. 44, # 18 p. 2752 - 2756

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被引用次数: 124

摘要

The mechanism of the enantioselective 1, 4-addition of Grignard reagents to α, β- unsaturated carbonyl compounds promoted by copper complexes of chiral ferrocenyl diphosphines is explored through kinetic, spectroscopic, and electrochemical analysis. On the basis of these studies, a structure of the active catalyst is proposed. The roles of the solvent, copper halide, and the Grignard reagent have been examined. Kinetic studies ...