Tetrahedron Letters

One-step double reduction of aryl nitro and carbonyl groups using hydrazine

E Diez-Cecilia, B Kelly, I Rozas

文献索引：Diez-Cecilia, Elena; Kelly, Brendan; Rozas, Isabel Tetrahedron Letters, 2011 , vol. 52, # 50 p. 6702 - 6704

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被引用次数: 13

摘要

Single-step reduction of aryl nitro and carbonyl groups to the corresponding synthetically useful alkyl-anilines occurs with excellent yields by treatment with hydrazine and a base in a solvent-free reaction. The method has been applied to a broad range of compounds with different properties. Investigations into the mechanism of the reduction reveal that each group is reduced independently. A mechanism is proposed for this novel reduction of ...