Tetrahedron

PS-IIDQ: a supported coupling reagent for efficient and general amide bond formation

E Valeur, M Bradley

文献索引：Valeur, Eric; Bradley, Mark Tetrahedron, 2007 , vol. 63, # 36 p. 8855 - 8871

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被引用次数: 23

摘要

Polystyrene-IIDQ, a polymer-supported coupling reagent, was synthesized in three steps from Merrifield resin in 86% overall conversion. This reagent efficiently coupled carboxylic acids to amines in good yields and high purities, required no pre-activation step, and was tolerant of the order of reagent addition. PS-IIDQ was observed to be more efficient than polymer-supported carbodiimides (PS-EDC and PS-DCC) and gave higher yields than ...