Synthesis of novel 2-nitroimidazole-tethered tricyclic quinolines, bearing a second heteroatom, and their in vitro evaluation as hypoxia-selective cytotoxins and …

MV Papadopoulou, HS Rosenzweig…

文献索引：Papadopoulou, Maria V.; Rosenzweig, Howard S.; Bloomer, William D. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1523 - 1525

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被引用次数: 6

摘要

Two novel nitroimidazole-based bioreductive compounds, 10-[3-(2-nitroimidazolyl)- propylamino]-3, 4-dihydro-1H-thiopyrano [4, 3-b] quinoline hydrochloride (8a) and 10-[3-(2- nitroimidazolyl) propylamino]-2-methyl-1, 2, 3, 4-tetrahydro-benzo [b]-1, 6-naphthyridine hydrochloride (8b) have been synthesized and evaluated in V79 cells as hypoxia-selective cytotoxins and radiosensitizers that target DNA through weak intercalation. Both ...