Synthetic Communications

A useful divinyl ketone equivalent

S Danishefsky, CF Yan

文献索引：Danishefsky,S.; Yan,C.F. Synthetic Communications, 1978 , vol. 8, # 4 p. 211 - 218

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被引用次数: 12

摘要

Abstract In our approach to steroids of the androstane 3, 17-dione type, we utilized 5- chloropent-1-ene-3-one (2) as a synthetic equivalent of divinyl ketone (3). 1–3 We were able to achieve the conversion of 2 to a product of the type 4 by the consecutive use of two different Michael donors, XH and YH. 4 While some success was realized with compound 2, it does not constitute a generally satisfactory solution. Thus, difficulties were often ...