Absolute configuration determination of 2-(2-oxo-3-indolyl) acetamide derivatives

OR Suárez-Castillo, M Meléndez-Rodríguez…

文献索引：Suarez-Castillo, Oscar R.; Melendez-Rodriguez, Myriam; Castelan-Duarte, Luis Enrique; Sanchez-Zavala, Maricruz; Rivera-Becerril, Ernesto; Morales-Rios, Martha S.; Joseph-Nathan, Pedro Tetrahedron Asymmetry, 2009 , vol. 20, # 20 p. 2374 - 2389

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被引用次数: 14

摘要

We describe a reliable method for determining the absolute configuration of 2-(2-oxo-3- indolyl) acetamides based on analysis of the 1H NMR spectra of their phenylethylamide diastereomers. The conformational preferences for two diastereomeric amides were calculated by DFT, which matched well with the experimental results. X-ray diffraction analysis allowed us to validate the method.