A comparison of the antibacterial and β-lactamase inhibiting properties of penam and (2, 3)-β-methylenepenam derivatives: The discovery of a new β-lactamase …
DD Keith, J Tengi, P Rossman, L Todaro, M Weigele
文献索引：Keith, D. D.; Tengi, J.; Rossman, P.; Todaro, L.; Weigele, M. Tetrahedron, 1983 , vol. 39, # 15 p. 2445 - 2458
The antibacterial potencies of 2a and 4 are shown to be diminished considerably from their penam analogues, penicillin G (1a) and mecillinam (3). Despite this, 2a is a substrate for bacterial β-lactamases, and compounds 6a, 8 and 10 were found to be β-lactamase inhibitors. Penicillin-binding protein (PBP) studies indicate that penicillin G and mecillinam have much greater affinity for these enzymes than the (2, 3)-β-methylenepenam ...
