Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C
…, V Talman, O Aitio, E Ekokoski, M Finel…
文献索引：Kang, Ji-Hye; Peach, Megan L.; Pu, Yongmei; Lewin, Nancy E.; Nicklaus, Marc C.; Blumberg, Peter M.; Marquez, Victor E. Journal of Medicinal Chemistry, 2005 , vol. 48, # 18 p. 5738 - 5748
... 10, 11) All PKCs are dependent on anionic phospholipids for activation, with phosphatidyl-l-serine being ... DBU, DMF, rt → 40 °C, 22 h (5b1−19); (d) Dowex 50W × 8, MeOH, 40 °C, overnight, 10 ... group of the template (I) and synthesized a group of compounds (15a−e) that lacked ...
