Synthesis and pharmacological properties of benzamide derivatives as selective serotonin 4 receptor agonists

S Sonda, K Katayama, T Kawahara, N Sato…

文献索引：Sonda, Shuji; Katayama, Kenichi; Kawahara, Toshio; Sato, Noriko; Asano, Kiyoshi Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 10 p. 2737 - 2747

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被引用次数: 14

摘要

A series of 4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl) benzamides with a polar substituent group at the 1-position of the piperidine ring was synthesized and evaluated for its effect on gastrointestinal motility. The benzoyl, phenylsulfonyl, and benzylsulfonyl derivatives accelerated gastric emptying and increased the frequency of defecation. One of them, 4-amino-N-[1-[3-(benzylsulfonyl) propyl] piperidin-4-ylmethyl]-5-chloro-2- ...