2-Arylidenedihydroindole-3-ones: design, synthesis, and biological activity on bladder carcinoma cell lines

B Gerby, A Boumendjel, M Blanc, PP Bringuier…

文献索引：Gerby, Bastien; Boumendjel, Ahcene; Blanc, Madeleine; Bringuier, Pierre Paul; Champelovier, Pierre; Fortune, Antoine; Ronot, Xavier; Boutonnat, Jean Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 208 - 213

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被引用次数: 20

摘要

2-Arylidenedihydroindole-3-ones were assayed for their antiproliferative and apoptotic abilities as potential drug candidates to treat bladder tumor. These compounds were tested on cell lines obtained from bladder tumors of various stages [superficial (pTa and pT1) vs. invasive (⩾ pT2)]. The most active compound (3c) inhibited the proliferation, induced apoptosis, and decreased the expression of p-Stat5 and p-Pyk2 in DAG-1 and RT112 ...