1, 3-Dialkyl-4-(iminoarylmethyl)-1H-pyrazol-5-ols. A series of novel potential antipsychotic agents

…, HA DeWald, DM Lustgarten, IC Pattison…

文献索引：Wise, Lawrence D.; Butler, Donald E.; DeWald, Horace A.; Lustgarten, David M.; Pattison, Ian C.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1807 - 1812

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被引用次数: 26

摘要

2-(Diethylamino)-N-[4-(2-fluorobenzoyl)-l, 3-dimethyl-1H-pyrazol-5-yl] acetamide (1) was recently found to have an antipsychotic-like profile in behavioral animal tests but, unlike clinically available antipsychotic agents, did not interact with dopamine receptors. Compound 1 was apparently metabolized to (5-amin0-1, 3-dimethyl-lH-pyrazol-4-yl)(2- fluorophenyl) methanone (2), which was both active in the behavioral animal tests and ...