The synthesis of a series of 1, 2, 3, 3a, 8, 8a-hexahydroindeno [2, 1-b] pyrrole 5- alkylcarbamates and their reaolution are reported. These compounds are structurally related to physostigmine with substitution of a methylene group in place of the NMe group at position 8 of physostigmine. Many of these 8-carbaphysostigmine analogues are more potent acetylcholinesterase inhibitors in vitro and less toxic in vivo than physostigmine. ...
