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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

The Journal of Organic Chemistry

Diazomethyl ketone derivatives of pyrimidine nucleosides

JA Montgomery, HJ Thomas

文献索引：Montgomery, John A.; Thomas, H. Jeanette Journal of Organic Chemistry, 1981 , vol. 46, # 3 p. 594 - 598

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被引用次数: 21

摘要

1, 5, 6, 8-Tetradeoxy-8-diazo-~-~-erythro-7-octulofuranosylthymine (20) and 5, 6, 8-trideoxy- 8-diazo-@-~-ribo-7-octulofuranosyluracil (31), pyrimidine nucleosides containing the reactive diazomethyl ketone function, were prepared from thymidine and uridine via their 5 '- aldehydes 2 and 22 by the Wittig reaction with (carbalkoxy-methy1ene) triphenylphosphoranes followed by modification of the side chains of 3, 4, and 23 and ...

(2R,3S,5R)-2-(4-diazo-3-oxobutyl)-5-(5-methyl-2,4-dioxo-3-(p-tolyl)-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl acetate结构式

(2R,3S,5R)-2-(4...

~25%

2,4(1H,3H)-Pyrimidinedione,1-[(2R,4S,5R)-5-(4-diazo-3-oxobutyl)tetrahydro-4-hydroxy-2-furanyl]-5-methyl结构式

2,4(1H,3H)-Pyri...

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(2R,3S,5R)-2-(羟基甲基)-5-(5-甲基-2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)四氢呋喃-3-基乙酸酯结构式

(2R,3S,5R)-2-(羟...

~%

2,4(1H,3H)-Pyrimidinedione,1-[(2R,4S,5R)-5-(4-diazo-3-oxobutyl)tetrahydro-4-hydroxy-2-furanyl]-5-methyl结构式

2,4(1H,3H)-Pyri...

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benzyl 3-O-acetyl-1,2,5,6-tetradeoxy-1-[3-(4-toluyl)thymin-1-yl]-β-D-erythro-hept-5-enofuranuronate结构式

benzyl 3-O-acet...

~%

2,4(1H,3H)-Pyrimidinedione,1-[(2R,4S,5R)-5-(4-diazo-3-oxobutyl)tetrahydro-4-hydroxy-2-furanyl]-5-methyl结构式

2,4(1H,3H)-Pyri...

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(2R,3S,5R)-2-(1,3-diphenylimidazolidin-2-yl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl acetate结构式

(2R,3S,5R)-2-(1...

~%

2,4(1H,3H)-Pyrimidinedione,1-[(2R,4S,5R)-5-(4-diazo-3-oxobutyl)tetrahydro-4-hydroxy-2-furanyl]-5-methyl结构式

2,4(1H,3H)-Pyri...

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benzyl 3-((2R,3S,5R)-3-acetoxy-5-(5-methyl-2,4-dioxo-3-(p-tolyl)-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)acrylate结构式

benzyl 3-((2R,3...

~%

2,4(1H,3H)-Pyrimidinedione,1-[(2R,4S,5R)-5-(4-diazo-3-oxobutyl)tetrahydro-4-hydroxy-2-furanyl]-5-methyl结构式

2,4(1H,3H)-Pyri...

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O3'-acetyl-5'-oxo-5'-deoxy-thymidine结构式

O3'-acetyl-5'-o...

~%

2,4(1H,3H)-Pyrimidinedione,1-[(2R,4S,5R)-5-(4-diazo-3-oxobutyl)tetrahydro-4-hydroxy-2-furanyl]-5-methyl结构式

2,4(1H,3H)-Pyri...

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3-O-acetyl-1,2,5,6-tetradeoxy-1-[3-(4-toluyl)thymin-1-yl)]-β-D-erythro-heptafuranuronic acid结构式

3-O-acetyl-1,2,...

~%

2,4(1H,3H)-Pyrimidinedione,1-[(2R,4S,5R)-5-(4-diazo-3-oxobutyl)tetrahydro-4-hydroxy-2-furanyl]-5-methyl结构式

2,4(1H,3H)-Pyri...

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b-D-ribo-Heptofuranuronic acid,1,5,6-trideoxy-1-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)- (9CI)结构式

b-D-ribo-Heptof...

~%

[4-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]-2-oxo-butylidene]-imino-azanium结构式

[4-[5-(2,4-diox...

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ethyl 1,5,6-trideoxy-2,3-O-isopropylidene-1-(uracil-1-yl)-β-D-ribo-heptofuranuronate结构式

ethyl 1,5,6-tri...

~%

[4-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]-2-oxo-butylidene]-imino-azanium结构式

[4-[5-(2,4-diox...

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benzyl 3-((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)propanoate结构式

benzyl 3-((2R,3...

~%

[4-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]-2-oxo-butylidene]-imino-azanium结构式

[4-[5-(2,4-diox...

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benzyl 2,3-di-O-benzoyl-1-(3-benzoyluracil-1-yl)-1,5,6-trideoxy-β-D-ribo-heptofuranuronate结构式

benzyl 2,3-di-O...

~%

[4-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]-2-oxo-butylidene]-imino-azanium结构式

[4-[5-(2,4-diox...

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ethyl 1,5,6-trideoxy-2,3-O-isopropylidene-1-(uracil-1-yl)-β-D-ribo-hept-5-enofuranuronate结构式

ethyl 1,5,6-tri...

~%

[4-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]-2-oxo-butylidene]-imino-azanium结构式

[4-[5-(2,4-diox...

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2,3-di-O-benzoyl-1-(3-benzoyluracil-1-yl)-1,5,6-trideoxy-β-D-ribo-heptafuranuronic acid结构式

2,3-di-O-benzoy...

~%

[4-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]-2-oxo-butylidene]-imino-azanium结构式

[4-[5-(2,4-diox...

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(2R,3R,4R,5R)-2-(3-benzoyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5-(3-chloro-3-oxopropyl)tetrahydrofuran-3,4-diyl dibenzoate结构式

(2R,3R,4R,5R)-2...

~%

[4-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]-2-oxo-butylidene]-imino-azanium结构式

[4-[5-(2,4-diox...

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