Tetrahedron

Controlled monohalogenation of phosphonates: A new route to pure α-monohalogenated diethyl benzylphosphonates

B Iorga, F Eymery, P Savignac

文献索引：Iorga, Bogdan; Eymery, Frederic; Savignac, Philippe Tetrahedron, 1999 , vol. 55, # 9 p. 2671 - 2686

全文：HTML全文

被引用次数: 49

摘要

Starting from diethyl benzylphosphonates, a wide variety of diethyl α-monofluoro, chloro, bromo and iodobenzylphosphonates have been obtained in pure form by a one-pot procedure. This high yielding method implies the intermediate protection of the benzyl anion with TMSCl followed by halogenation with an electrophilic halogenating reagent.