Abstract The lithium enolate derived from benzamidoacetone (1) can be regiospecifically alkylated at C (1) and stereospecifically added in conjugate fashion to cyclohexenone without resorting to protection of the free NH. Comparison is made with alkylations of methyl hippurate.
[Weiner, Barbara; Baeza, Alejandro; Jerphagnon, Thomas; Feringa, Ben L. Journal of the American Chemical Society, 2009 , vol. 131, # 27 p. 9473 - 9474]
