New cyclooxygenase-2/5-lipoxygenase inhibitors. 1. 7-tert-butyl-2, 3-dihydro-3, 3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and …
…, JM Ridgeway, MW Scherz, K Enzweiler…
文献索引：Janusz, John M.; Young, Patricia A.; Ridgeway, James M.; Scherz, Michael W.; Enzweiler, Kevin; Wu, Laurence I.; Gan, Lixian; Darolia, Renuka; Matthews, Randall S.; Hennes, Duane; Kellstein, David E.; Green, Shelley A.; Tulich, Jennifer L.; Rosario-Jansen, Theresa; Magrisso, I. Jack; Wehmeyer, Kenneth R.; Kuhlenbeck, Deborah L.; Eichhold, Thomas H.; Dobson, Roy L. M.; Sirko, Steven P.; Farmer, Ralph W. Journal of Medicinal Chemistry, 1998 , vol. 41, # 7 p. 1112 - 1123
A series of 5-keto-substituted 7-tert-butyl-2, 3-dihydro-3, 3-dimethylbenzofurans (DHDMBFs) were prepared and evaluated as potential nonsteroidal antiinflammatory and analgesic agents. Interest in this class of compounds arose when a DHDMBF was found to be an active metabolite of the di-tert-butylphenol antiinflammatory agent tebufelone. We have now found that a variety of 5-keto-substituted DHDMBFs have good in vivo antiinflammatory ...
