Organic letters

A Novel 1, 5-Benzoheteroazepine Synthesis via a One-Pot Coupling-Isomerization-Cyclocondensation Sequence §

RU Braun, K Zeitler, TJJ Müller

文献索引：Braun, Roland U.; Zeitler, Kirsten; Mueller, Thomas J. J. Organic Letters, 2000 , vol. 2, # 26 p. 4181 - 4184

全文：HTML全文

被引用次数: 53

摘要

2, 4-Di (hetero) aryl substituted 2, 3-dihydro 1, 5-benzoheteroazepines (hetero= NH, O, S) can be readily sythesized in a one-pot process initiated by a coupling-isomerization sequence of an electron poor (hetero) aryl halide and a terminal propargyl alcohol subsequently followed by a cyclocondensation with 2-amino, 2-hydroxy, or 2-mercapto anilines. In addition, the structures were established unambiguously by an X-ray structure ...