Tetrahedron letters

A new entry for the synthesis of N-acyl-N′-substituted guanidines

T Shinada, T Umezawa, T Ando, H Kozuma, Y Ohfune

文献索引：Shinada, Tetsuro; Umezawa, Taiki; Ando, Tsuyoshi; Kozuma, Hayato; Ohfune, Yasufumi Tetrahedron Letters, 2006 , vol. 47, # 12 p. 1945 - 1947

全文：HTML全文

被引用次数: 21

摘要

These facts lead to extensive efforts for the synthesis of this class of acylguanidines. Herein, we wish to report a simple method to access N-acyl-N′-substituted guanidines by condensation of N-acyl-N′-substituted thiourea 1 with hexamethyldisilazane (HMDS) as a nitrogen source under the mild reaction conditions (Scheme 1). ... With the optimized reaction conditions in hand, the scope and limitation of this method were examined (Scheme 3, Table 2). ...