Anti-AIDS agents—XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues

…, Y Kashiwada, BN Zhou, P Wang, LM Cosentino…

文献索引：Chen, Dao-Feng; Zhang, Shun-Xiang; Xie, Lan; Xie, Jing-Xi; Chen, Ke; Kashiwada, Yoshiki; Zhou, Bing-Nan; Wang, Pei; Cosentino, L. Mark; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1715 - 1723

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被引用次数: 174

摘要

Bioactivity-directed fractionation of an ethanolic extract of the stems of Kadsura interior led to the isolation and identification of 12 known lignans (1–12). Seven of these compounds (1, 6, 8–12) were active as anti-HIV agents. Gomisin-G (11) exhibited the most potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 μg/mL and 300, respectively. Schisantherin-D (6), kadsuranin (8), and schisandrin-C (10) showed good activity with ...