6-Phenyl-6-alkylamido-5, 6-dihydro-2H-pyran-2-ones: novel HIV protease inhibitors

…, C Gajda, SE Hagen, D Ferguson, EA Lunney…

文献索引：Hamilton, Harriet W.; Tait, Bradley D.; Gajda, Christopher; Hagen, Susan E.; Ferguson, Donna; Lunney, Elizabeth A.; Pavlovsky, Alexander; Tummino, Peter J. Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 6 p. 719 - 724

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被引用次数: 12

摘要

Publications from our laboratories have recently described a series of 3-thioaryl substituted- 4-hydroxy-pyrones1 as HIV protease inhibitors. The current work examines the analogous 5, 6-dihydro-2H-pyran-2-ones with 6, 6-substitutions focusing on the use of 1°, 2°, and 3° alkyl amides of various chain lengths to fill the S1 through S3 enzyme pockets.