Organic letters

A highly enantioselective Lewis Basic organocatalyst for reduction of N-aryl imines with unprecedented substrate spectrum

Z Wang, X Ye, S Wei, P Wu, A Zhang, J Sun

文献索引：Wang, Zhouyu; Ye, Xiaoxia; Wei, Siyu; Wu, Pengcheng; Zhang, Anjiang; Sun, Jian Organic Letters, 2006 , vol. 8, # 5 p. 999 - 1001

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被引用次数: 124

摘要

l-Pipecolinic acid derived formamides have been developed as highly efficient and enantioselective Lewis basic organocatalysts for the reduction of N-aryl imines with trichlorosilane. Catalyst 4b afforded high isolated yields (up to 98%) and enantioselectivities (up to 96%) under mild conditions with an unprecedented substrate spectrum.