Novel nonopioid non-antiinflammatory analgesics: 3-(aminoalkyl)-and 3-[(4-aryl-1-piperazinyl) alkyl] oxazolo [4, 5-b] pyridin-2 (3H)-ones

C Flouzat, Y Bresson, A Mattio, J Bonnet…

文献索引：Flouzat, Christine; Bresson, Yvette; Mattio, Anny; Bonnet, Jacqueline; Guillaumet, Gerald Journal of Medicinal Chemistry, 1993 , vol. 36, # 4 p. 497 - 503

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被引用次数: 43

摘要

A series of 3-(aminoalk yl)-and 3-[(4-aryl-1-piper azin yl) alkyl] oxazolo [4, 5-b] p yr idin-2 (3H)-ones were prepared from their respective oxazolo [4, 5-b] pyridin-2 (3H)-ones. Several members of this group were found to possess potent analgesic activity in the mouse during a p-phenylquinone writhing induced test. Among them, phenylpiperazine compounds with two- carbon length alkyl chains, 2a and 2b, appeared by high analgesic with little toxicity ...