Synthesis of marine alkaloid: 8, 9-dihydrocoscinamide B and its analogues as novel class of antileishmanial agents

…, A Talwar, S Palne, S Gupta, PMS Chauhan

文献索引：Gupta, Leena; Talwar, Archna; Nishi; Palne, Shraddha; Gupta, Suman; Chauhan, Prem M.S. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 14 p. 4075 - 4079

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被引用次数: 44

摘要

A series of marine alkaloid 8, 9-dihydrocoscinamide B, its analogues and indolylglyoxylamide derivatives have been synthesized and screened for their in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 7 and 10 have shown 99–100% inhibition against promastigotes and 97–98% inhibition against amastigotes at a concentration of 10μg/ml.