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Bioorganic & medicinal chemistry

Antiangiogenic and antitumor agents: design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo [2, 3-d] pyrimidines as …

A Gangjee, J Yang, MA Ihnat, S Kamat

文献索引:Gangjee, Aleem; Yang, Jie; Ihnat, Michael A.; Kamat, Shekhar Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5155 - 5170

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被引用次数: 39

摘要

Several different classes of growth factor receptors containing tyrosine kinases (RTK) are directly or indirectly involved in angiogenesis. Inhibition of these RTKs has provided a new paradigm in the treatment of tumors by restricting their growth and metastasis. We have designed, synthesized and evaluated eleven novel 2-amino-4-(3-bromoanilino)-6- substituted benzyl pyrrolo [2, 3-d] pyrimidines as the first in a series of RTK inhibitors. ...

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