Tetrahedron letters

Phosphonium supported triphenylphosphine reagent: an improved access to α-fluoro-α, β-unsaturated esters

…, C Lacombe, JC Quirion, AB Charette, P Jubault

文献索引：Zoute, Ludivine; Lacombe, Celine; Quirion, Jean-Charles; Charette, Andre B.; Jubault, Philippe Tetrahedron Letters, 2006 , vol. 47, # 45 p. 7931 - 7933

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被引用次数: 20

摘要

α-Fluoro-α, β-unsaturated esters 2 were efficiently synthetized via diethylzinc-promoted Wittig reaction using a phosphonium-supported triphenylphosphine SCG–PPh31, which possesses similar reactivity as its parent analog triphenylphosphine. The main advantage of this system is the use of a novel low-molecular-weight support that is soluble in solvents of medium polarities for the attachment of reagents and insoluble in solvents of low polarities.