Tetrahedron

Electrosynthesis of fluorinated indole derivatives

B Yin, L Wang, S Inagi, T Fuchigami

文献索引：Yin, Bin; Wang, Laihao; Inagi, Shinsuke; Fuchigami, Toshio Tetrahedron, 2010 , vol. 66, # 34 p. 6820 - 6825

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被引用次数: 17

摘要

Anodic fluorination of various N-acetyl-3-substituted indole derivatives was successfully carried out in Et4NF-4HF/MeCN to provide the corresponding trans-2, 3-difluoro-2, 3- dihydroindoles exclusively or selectively. Treatment of difluorinated products with a base provided monofluoroindole derivatives or monofluoroindoline derivative depending on the substituents at the 3-position.