One-pot synthesis of tetrasubstituted pyrazoles—Proof of regiochemistry

U Hanefeld, CW Rees, AJP White…

文献索引：Hanefeld, Ulf; Rees, Charles W.; White, Andrew J. P.; Williams, David J. Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 13 p. 1545 - 1552

全文：HTML全文

被引用次数: 86

摘要

1-Alkyl-5-amino-3-aryl-4-cyanopyrazoles, useful intermediates for fused heterocyclic systems, are synthesised by a one-pot three-step procedure from acid chlorides, malononitrile and alkylhydrazines. The regiochemistry of the hydrazine incorporation was proved in each case by X-ray crystallography and NMR spectroscopy.