Organic letters

Electrocyclic ring closure of the enols of vinyl quinones. A 2H-chromene synthesis

KA Parker, TL Mindt

文献索引：Parker, Kathlyn A.; Mindt, Thomas L. Organic Letters, 2001 , vol. 3, # 24 p. 3875 - 3878

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被引用次数: 68

摘要

Thermolysis of enolizable vinyl quinones in polar, aprotic media provides 2H-chromenes. Experimental evidence supports a two-step mechanism in which enolization is followed by a thermal 6π-electrocyclic reaction of an intermediate quinone methide. Application of this method led to the total synthesis of the reputed structure of an Ageratum juvenile hormone. When enolizable vinyl quinones are the products of Stille coupling, the chromene ...