Synthesis of Arrays Using Low Molecular Weight MPEG-Assisted Mitsunobu Reaction
M Figlus, N Wellaway, AWJ Cooper…
文献索引：Figlus, Marek; Wellaway, Natalie; Cooper, Anthony W. J.; Sollis, Steven L.; Hartley, Richard C. ACS Combinatorial Science, 2011 , vol. 13, # 3 p. 280 - 285
Triphenylphosphine tagged with a short poly (ethyleneglycol)-ω-monomethyl ether chain (light MPEG, 10− 16 ethylenoxy units, MTPP-G2) and an MPEG-tagged version of diethyl azodicarboxylate (MDEAD) have been used to prepare a 20 member library of esters, ethers, and sulfonamides, with cLogP's in the range of 1.4− 5.7 on a 0.1 mmol scale. Removal of MPEG-tagged side products was achieved by MPEG-assisted solid-phase ...
