Tetrahedron Letters

Efficient ligand-free copper-catalyzed N-arylation of amides with aryl halides in water

FF Yong, YC Teo, GL Chua, GS Lim, Y Lin

文献索引：Yong, Fui-Fong; Teo, Yong-Chua; Chua, Guan-Leong; Lim, Gina Shiyun; Lin, Yizhen Tetrahedron Letters, 2011 , vol. 52, # 11 p. 1169 - 1172

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被引用次数: 18

摘要

A convenient and efficient protocol has been developed for the cross-coupling of amides and aryl iodides using a ligand-free copper (I) oxide catalyst in water. A variety of amide derivatives afforded the corresponding N-arylated products in moderate to good yields (up to 88%).