Synthesis and pharmacological activity of O-aminoalkyl derivatives of 7-hydroxycoumarin

JT Konc, E Hejchman, H Kruszewska, I Wolska…

文献索引：Trykowska Konc, Joanna; Hejchman, Elzbieta; Kruszewska, Hanna; Wolska, Irena; Maciejewska, Dorota European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2252 - 2263

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被引用次数: 12

摘要

A series of novel O-aminoalkyl substituted 7-hydroxycoumarins were synthesized and evaluated for antibacterial and anticancer toxicity. Two different synthetic procedures, conventional and microwave assisted were used, and the structures of the compounds were confirmed by IR, 1H, 13C NMR and MAS spectroscopic data. The molecular and crystal structures of 8-acetyl-7-[2-(1-morpholino) ethoxy] 4-methylchromen-2-one in solid state ...