Angiotensin converting enzyme inhibitors.(Mercaptoaroyl) amino acids

…, ES Neiss, J Wilde, A Schwab, WS Mann

文献索引：Menard; Suh; Jones; Loev; Neiss; Wilde; Schwab; Mann Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 328 - 332

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被引用次数: 14

摘要

A series of (mercaptoaroy1) amino acids and related compounds was synthesized and tested for ability to inhibit angiotensin converting enzyme (ACE). The most active compound was N-(3-chloro-2-mercaptobenzoyl)-N-cyclo-pentylglycine, having an in vitro Im= 0.28 fiM. Substitution of the aromatic 3-position by small polar groups enhanced ACE inhibitory activity, whereas bulky groups diminished it. Alteration of the@ relationship between the ...