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Australian journal of chemistry

The synthesis of two combinatorial libraries using a 4-(2-thienyl)-pyrrole template

RA Davis, AR Carroll, RJ Quinn

文献索引:Davis, Rohan A.; Carroll, Anthony R.; Quinn, Ronald J. Australian Journal of Chemistry, 2002 , vol. 55, # 12 p. 789 - 794

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被引用次数: 0

摘要

Abstract The synthesis of the novel biaryl compound, 4-(2-thienyl)-1H-pyrrole-2- carbaldehyde (1), by Suzuki–Miyaura coupling conditions is reported. Compound (1) was subsequently used as a combinatorial template in the parallel solution-phase synthesis of an amine and imine compound library. The amine library was produced using reductive amination conditions, and purification was achieved by a liquid–liquid partition followed ...