Synthetic Communications

The Reaction of Organozinc Reagents with Bis (N-Butoxymethyl)-t-Butylamine

PY Johnson, I Jacobs

文献索引：Johnson,P.Y.; Jacobs,I. Synthetic Communications, 1974 , vol. 4, p. 51 - 56

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摘要

Abstract In connection with our synthetic studies of new anticancer agents1 we required the hindered amino diester 1. Our recent success2 with dialkylation reactions involving bis (chloromethyl) ether and Reformatsky reagents, leading to the synthesis of the oxygen analog of 1, 2, suggested a similar approach might be successful if applied to the synthesis of 1. Since bis (chloromethyl) amines have never been isolated to our knowledge and ...