Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization

M Cushman, D Nagarathnam, D Gopal…

文献索引：Cushman, Mark; Nagarathnam, Dhanapalan; Gopal, D.; Chakraborti, Asit K.; Lin, Chii M.; Hamel, Ernest Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2579 - 2588

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被引用次数: 310

摘要

An array of cis-, trans-, and dihydrostilbenes and some N-arylbenzylamines were synthesized and evaluated for their cytotoxicity in t. he five cancer cell cultures A-549 lung carcinoma, MCF-7 breast carcinoma, HT-29 colon adenocarcinoma, SKMEL-5 melanoma, and MLM melanoma. Several cis-stilbenes, structurally similar to combretastatins, were highly cytotoxic in all five cell lines and these were also found to be active as inhibitora of ...