Tetrahedron Letters

Nickel-mediated amination chemistry. Part 2: Selective N-arylation or N, N′-diarylation of piperazine

E Brenner, R Schneider, Y Fort

文献索引：Brenner, Eric; Schneider, Raphael; Fort, Yves Tetrahedron Letters, 2000 , vol. 41, # 16 p. 2881 - 2884

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被引用次数: 48

摘要

The 2, 2′-bipyridine liganded Ni catalyst has revealed a good selectivity in the mono arylation of piperazine starting from aryl chlorides allowing a selective and efficient synthesis of N-arylpiperazines using stoichiometric amounts of reagents. The preparation of N, N′- diaryl substituted piperazines is also described.