Synlett

Synthesis of Quinazolines and Imidazo [1, 2-c] quinazolines with the Aid of a Low-Valent Titanium Reagent

D Shi, J Wang, C Shi, L Rong, Q Zhuang, H Hu

文献索引：Shi, Daqing; Wang, Juxian; Shi, Chunling; Rong, Liangce; Zhuang, Qiya; Hu, Hongwen Synlett, 2004 , # 6 p. 1098 - 1100

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被引用次数: 18

摘要

Abstract A short and facile synthesis of a series of quinazolines and imidazo [1, 2-c] quinazolines was accomplished in good yields via the novel reductive cyclization of 2- nitrobenzyl amines or 2-(2-nitrophenyl) imidazoles with ortho-ester, aldehydes or ketones promoted by TiCl 4/Zn system. The structures were established by spectroscopic data and confirmed by X-ray analysis.