Prevalence of cis-addition products in the reaction of the butenyl Grignard reagent with sterically hindered ketones

RA Benkeser, WG Young, WE Broxterman…

文献索引：Benkeser,R.A. et al. Journal of the American Chemical Society, 1969 , vol. 91, # 1 p. 132 - 137

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被引用次数: 43

摘要

Abstract: The reactions of crotylmagnesium bromide with ethyl isopropyl, diisopropyl, isopropyl t-butyl, and di-t-butyl ketones have been examined under carefully controlled conditions. The quantity of a-methylallylcarbinol formed in each case was found to decrease and the amount of crotylcarbinol to increase progressively as the steric requirements of the alkyl groups attached to the carbonyl of the ketone increased. This observation probably ...