Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 3. Modifications to the linkage region (region 3)

DM Stout, WL Matier, C Barcelon-Yang…

文献索引：Stout; Matier; Barcelon-Yang; Reynolds; Brown Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 295 - 298

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被引用次数: 19

摘要

As part of a continuing program of systematically modifying the structure of the class I antiarrhytbic drug changrolin, we synthesized 15 analogues in which the linkage between the two aromatic regions was altered. High antiarrhythmic activity and low parasympatholytic activity was found when the linkage region, designated region 3, contained a carbonyl moiety, including ketones, amides, and ureas. Secondary amides were superior to tertiary ...